ephedra alata cancer

Mayo Clin Proc. We do not recommend using herbal sources of ephedrine, which are now banned, for weight loss at all. 1995;3:537S-540S. heart attack Adverse cardiovascular events temporally associated with Ma Huang, an herbal source of ephedrine. Heinrich M, Ankli A, Frei B, Weimann C, Sticher O. The first double-blind placebo-controlled pilot study in adolescents. Previous studies showed that Dalbergia sissoo exerted antimicrobial, neural, cardiac, antioxidant, antiparasitic,antidiabetic,anti-inflammatory,analgesic, Osteogenic, dermatological, gastrointestinal, reproductive and many other effects. Categorical variables were compared using Chi-squared and Fisher’s exact tests, as applicable. Éditions des. A questionnaire was distributed to one hundred and fifty herbalists, traditional healers and rural dwellers. It possessed antibacterial, anti-inflammatory, antipyretic, analgesic, antioxidant, gastrointestinal, cardiovascular, diuretic, dermatological and many other effects. It is can be calculated according to the following equation: Where UV is the use value of a species; U the number of citations per species; n the number of informants [30]. Ephedra is a stimulant that has caused heart attack and stroke resulting in several deaths. It is a species of Ephedra that grows mostly in the desert. 2014;23:249–54. The current review discussed the chemical constituents and pharmacological activities of Dolichos lablab. One highly preliminary study has been used to claim that ephedrine is helpful for women with The effect of ephedrine plus caffeine on smoking cessation and postcessation weight gain. Any stimulant drugs (including caffeine): Do not take ephedra except under physician supervision. The FDA has banned the sales of dietary supplements that contain ephedra because of their significant risk to human health (12) (13). We're committed to providing you with the very best cancer care, and your safety continues to be a top priority. 3. This article provides the knowledge about anticancer medicinal plants of local and foreign origin, which are used by the people all over the Palestinian area in addition to their method of preparation. The roots were used as aphrodisiac (1, 3-4). Available at: Due to the high death rate among patients with cancer and the hazardous side effects and adverse reactions of the radiotherapy and chemotherapy, cancer patients often start seeking alternative methods of treatments, like herbal medicine with or instead of conventional medicine [24–26]. 2006;3:229–35. The non compartmental kinetic was fitted and the parameters were calculated by Kinetica 5.0.11 software, so as to evaluate the effect of Cinnamomi Ramulus on the distribution kinetics of E and PE from Ephedrae Herba in brain tissues of mice. // End -->. This effect, however, may lead to other cardiovascular adverse reactions such as stroke and heart attack (8). For adults, no more than 25 mg should be taken at one time, and a total daily intake of 100 mg should not be exceeded.12 However, a survey of ephedra-containing dietary supplements found that ephedrine content as listed on the label was frequently incorrect.13 The extract possessed antifungal activity against all the tested fungi. In most cases, the interviews often started in the form of informal discussions to gain the confidence of the interviewees. Food and Drug Administration website. The total alkaloids contents of Ephedra foliata (ephedrine and psudoephedrine) were 0.04-0.2%. Azaizeh H, Saad B, Khalil K, Said O. ethyl acetate and dichloromethane extracts of leaves. Fic values obtained for the reported cancers indicate the degree of shared knowledge among informants for the treatment of a cancer by certain medicinal plants. • These two species were active against MCF-7 breast cancer cell line. The false positive reaction of the Triage panel drug-of-abuse by herbal drugs ma-huang (Ephedra sinica Ephedraceae). Breum L, Pedersen JK, Ahlstrom F, et al. Moreover, clinical studies approved according to international guidelines should be considered in order to prove the safety and efficacy of treatment, especially for the most frequently reported medicinal plants. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. 1910. Ovadje P, Roma A, Steckle M, Nicoletti L, Arnason JT, Pandey S. Advances in the Research and Development of Natural Health Products as Main Stream Cancer Therapeutics. BMC Complement Altern Med 16, 93 (2016). What Is the Scientific Evidence for Ephedra? 1834. According to the World Health Organization (WHO) evaluations, about 80 % of populations in developing countries have utilized ethno-medicines for their health care requirements and more than 60 % of cancer patients have used natural plant products with vitamins in fighting this disease [13–15]. Therefore minor restrictions could be included as they have minor risk compared to the obtained therapeutic benefits from their use for cancer. The Fic was high for all the plants; Fl was 100 % for many plants, the highest UV (0.72) was for Ephedra alata. Please let us know what you think of our products and services. Ephedrine production from suspension cultures of Ephedra alata L. callus, Phenolics and flavonoids contents of medicinal plants, as natural ingredients for many therapeutic purposes- A review, Antibacterial effect of the phenolic extract of Alhagi maurorum, Medicinal plants possessed hepatoprotective activity, Antifungal effect of Alhagi maurorum phenolic extract, Iraqi Medicinal Plants with Antibacterial Effect-A Review, STANDARDIZATION AND PHYTOCHEMICAL SCREENING ACTIVITY OF Abrus Precatorius Linn ROOT EXTRACTS, Antibacterial effects of Medicinal Plants, HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECTS OF THE AQUEOUS EXTRACT OF TURMERIC (CURCUMA LONGA) IN RIFAMPICIN AND ISONIAZID-INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATS, A review on Fagopyrum esculentum: A potential medicinal plant, Nutritional and pharmacological importance of Ficus carica -A review, Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)-A review, Nutritional and therapeutic importance of Daucus carota-A review, Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium -A review, Chemical constituents and pharmacological effects of Dalbergia sissoo -A review, The pharmacology of Equisetum arvense-A review, The pharmacology and medical importance of Dolichos lablab (Lablab purpureus)-A review, A review on Dodonaea viscosa: A potential medicinal plant. Alkaloids in Ephedra sinica transitionally crossed blood brain barrier (BBB) and the distribution were investigated. Contrary to some reports, participants did not develop tolerance to the treatment. Physico-chemical parameters such as moisture level, total ash, ash soluble in water and values of sulfated ash were measured. Leaves very short, united towards base, forming short sheath. 2011;17:235–40. Sahoo N, Manchikanti P, Dey S. Herbal drugs: standards and regulation. The Fic was high for all the plants; Fl was 100 % for many plants, the highest UV (0.72) was for Ephedra alata. if (theYear < 1900) theYear += 1900; Ben-Arye E, Schiff E, Hassan E, Mutafoglu K, Lev-Ari S, Steiner M, et al. The other factors to be considered are the harvesting time of the herb (collection time), the soil, the climate conditions, and the method of drying, processing, and extraction [37, 38]. 2001;55:331-338. Obes Res. Ben-Arye E, Samuels N. Homeopathy on the crossroads of traditional and integrative medicine in the Middle-East. Safety and efficacy of treatment with an ephedrine/caffeine mixture. The dosage of ephedra should be adjusted according to the amount of the ephedrine it provides. This proportion is particularly impressive given that less than 1% of all herbal products sold in the US contained ephedra. They activate the “fight or flight” response, resulting in constriction of blood vessels, relaxation and dilation of air passages, appetite suppression, and general stimulant effects. PubMed Google Scholar. These informants represented most of the practitioners in this field in the West Bank (Sociodemographic characteristics are presented in Table 1). C. Male branch. Side effects of adjuvant treatment of breast cancer. United States Department of Health and Human Services. These ancient warnings seem to have been disregarded in the transition of ephedra use from Asia to the United States, where it had often been sold for continuous use by overweight, relatively unhealthy people. Collected information included the names of plants, the used parts, types of cancers for which these plants were used and also their methods of preparation. The current paper reviewed the chemical constituents, nutritional and pharmacological importance of Ficus carica. In recent time, people in both developed and developing countries utilize herbal medicines for improving their health [10–12]. Where additional assistance is needed in body fat reduction, individuals should consult a registered dietitian or their physician. 280. Ethnobotanical survey of traditional medicinal plants in Tehuledere district, South Wollo. In an approach toward the development of ecofriendly antifungal compounds for controlling major fungal diseases, many medicinal plants possessed wide range of antifungal activities (16)(17)(18)(19)(20) , some of them were formulated and used clinically nowadays. fruits and vegetables) will provide health-protective effects. All rights reserved. A. Evidence suggests that ephedrine/caffeine combinations can aid Keith, H. G. 1965. A few side effects were seen in this study, primarily insomnia, dizziness, and tremor, but they tended to fade away after a few weeks. Molnar D, Torok K, Erhardt E, et al. 2000;24:1573-1578. Available at: Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Article  The author provides answers to today's naturopathic questions by paying particular attention to the chronic diseases engendered by obesity, as well as Alzheimer's, cancer, imbalances of neurotransmitters such as Parkinson's, and depression. Lee MK, Cheng BW, Che CT, et al. Danciu, Corina; Muntean, Delia; Alexa, Ersilia; Farcas, Claudia; Oprean, Camelia; Zupko, Istvan; Bor, Andrea; Minda, Daliana; Proks, Maria; Buda, Valentina; Hancianu, Monica; Cioanca, Oana; Soica, Codruta; Popescu, Sofia; Dehelean, Cristina A. The results showed that the ephedrine/caffeine treatment significantly enhanced weight loss, resulting in a loss of more than 36 pounds as compared to only 29 pounds in the placebo group, a 7-pound difference. Hypersensitivity myocarditis associated with ephedra use 1997;17:437-439. and help keep the weight off for up to 6 months. Plants provide a continual source of medicines for animals and humans; they have been used since ancient times in crude forms as decoctions, syrups, liniments, powders, infusions and ointments [6, 7]. Evidence of medicinal plant use around 60 000 years ago was found in a cave discovered in 1960 in the Middle East [8, 9]. Notably the results of this research have revealed that 72 plant species belonging to 44 families were frequently used for treatment of cancer by the 150 herbalists, traditional practitioner healers, rural dwellers and people of the West Bank, Palestine (Table 2). myocardial infarction or cerebrovascular accident [71]. Methods of preparation were mainly decoction and infusion. In many countries, it is used as a popular, effective medicinal herb. Female cone showing the membranous, winged bract. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line. PubMed  Jaradat N. Ethnopharmacological survey of natural products in palestine. A convenience sample of herbalists and practitioners from various regions were met by researchers and asked to answer a face to face questionnaire. Safety Issues.). 1996;91:1436-1438. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Astrup A, Breum L, Toubro S. Pharmacological and clinical studies of ephedrine and other thermogenic agonists. 2, 300041 Timişoara, România, Department of Food Control, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului No. Solecki RS. Map of the West Bank/ Palestine showing all surveyed regions. 2005;19. Bilateral acute myopia and angle closure glaucoma induced by Ma-huang (Ephedra): A case report. Content versus label claims in ephedra-containing dietary supplements. Eur J Gastroenterol Hepatol. A randomized, placebo-controlled, crossover study of ephedrine for SSRI-induced female sexual Dysfunction. Medicinal plants possessed antibacterial activities via many mechanisms, such as disruption of cytoplasmic membrane, inhibition of cell wall synthesis, inhibition of cell membrane synthesis, inhibition of nucleic acid synthesis, inhibition of energy metabolism, as well as inhibition of bacterial virulence factors, including quorum-sensing signal receptors, enzymes and toxins. Int J Obes Relat Metab Disord. California Privacy Statement, Pharmacognosy: Science of natural products in drug discovery. http://www.medscape.com/MedscapeWire/2000/08...medwire.0816.Nol, http://www.fda.gov/bbs/topics/NEWS/2006/NEW01434.html, http://www.fda.gov/oc/initiatives/ephedra/febru...2004/default.htm. Today, the main importance of Ephedra species in the medical field is due to the presence of the alkaloids derived from phenyl-alanine, which act on the sympathetic nervous system as a sympathomimetic. 2012;140:624–33. Herbal medicines in cancer care in the Palestinian Authority. A total of 103 overweight individuals were enrolled in this 15-week, double-blind trial. Danciu C, Muntean D, Alexa E, Farcas C, Oprean C, Zupko I, Bor A, Minda D, Proks M, Buda V, Hancianu M, Cioanca O, Soica C, Popescu S, Dehelean CA. There are many reasons for this high rate of risk. Department of Pharmacology, College of Medicine, Thi qar University, Iraq. Interviews were conducted in the Arabic language of the informants. Arch Gen Psychiatry. 2005;2:475–9. chemical structure and biological function to amphetamine, although having a 25-fold lower biological potency. In addition to that it was as an important international trade crossroad from ancient times, between North Africa, East Asia and West Europe; this added to its culture in herbal medicines [3–5]. Astrup A, Breum L, Toubro S, et al. The Latest Research Incorporating current research on the devastating role of chronic systemic inflammation and the cumulative effect of poor oxygen metabolism and free radicals on changes in mitochondrial DNA, enzyme activity, and accelerations in the aging process, the text bridges the gap between ancient remedies and modern knowledge Effective Treatment Deconstructing the molecular mystery that is the interaction among herbal properties, physiology, and disease, Pharmacodynamic Basis of Herbal Medicine, Second Edition opens the door to successful herbal treatment. http://dx.doi.org/10.2305/I, http://www.gbif.org/species/2653400 /synonyms. In addition, it required more, ephedrine was only about one thousandth as active. 2297. rats. To have the expected benefits, the patients should receive a fixed well defined dosage, but in traditional medicine the suitable doses are not clear [37], so studies are needed to determine the concentration of active ingredients depending on their method of preparation to give the suitable recommended doses. Even a single dose of an ephedra containing supplement can cause dangerous increases in blood pressure and effects on heart function. http://plants.usda.gov/java/ClassificationServlet?source, grin.gov/gringlobal/taxonomydetail.aspx?15213, e.T201696A9167394. This research shows that the medicinal plants still play a role in the care of cancer patients in Palestine. $$ \mathrm{U}\mathrm{V}-\frac{{\displaystyle \sum U}}{n} $$, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12906-016-1070-8. 1:455. FDA Acts to Remove Ephedra-Containing Dietary Supplements From Market. Meston CM. The highest one (40.74 %) was for liver cancer. In a previous study from Palestine, 60.9 % of cancer patients reported using medicinal herbs [35]. The previous pharmacological studies of Datura fastuosa showed that it possessed antimicrobial insecticidal, antidiabetic, cytotoxic, antioxidant, antiinflammatory, analgesic, antipyretic, neurological, wound healing, reproductive and antispasmodic, while Datura stramonium exerted Antiepileptic, Anti-asthmatic, analgesic, antioxidant, antimicrobial, insecticidal, repellent and organophosphate protective effects. weight loss.1-5,19,31Note: Due to safety risks, we strongly recommend that you seek physician's supervision before attempting to lose weight with ephedrine/caffeine combination therapy. jemail("earlecj", "gmail", "com"); This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Ann Onco. More than half of all cancers and cancer deaths occurred in less developed countries, and these proportions may be further increased [18–20]. The previous studies revealed that Equisetum arvense contained alkaloids, carbohydrate, proteins and amino acids, phytosterols, saponins, sterols, ascorbic acid, silicic acid, phenol , tannin, flavonoids, triterpenoids, volatile oils and many other biological active constituents. The recently developed locally distributed origin gauge model for VCD was used to calculate VCD spectra of the conformers for each drug. Article  Factor of informant’s consensus (Fic) was employed to indicate how homogenous the information is. Ephedra's other major ingredient, pseudoephedrine, became the decongestant Sudafed. P2. Nidal Amin Jaradat. Questionnaires were administered through personal contact discussions. One of the essential medicinal plants belonging to the Fabaceae family is Abrus precatorius. Ephedra alata Decne. The main problem is destructive harvesting of the subterranean parts of the medicinal plants, or even the entire plant.

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